Programme

09:00 Registration

09:50 Opening and Plenary Lecture
Session 1: NVE Lecture
Chair: Susanne la Fleur (Amsterdam)
Dana Small (New Haven, CT, USA) It must be my metabolism: metabolic control of mind (60')

11:00 Coffee/Tea

11:30 Parallel Sessions A
Session 2: Brain-immunology axis, vagal activity and the neuronal reflex
Chair: Wouter de Jonge (Amsterdam)
Willem Buurman (Maastricht) Nutritional activation of the vagal immune modulating pathway (30')
Misha Luyer (Eindhoven) The effects of gum chewing on postoperative ileus and inflammation; a prospective randomized controlled trial (15')
Lea Costes (Amsterdam) Sympathetic rather than vagal activity modulates colonic inflammation in acute DSS-induced colitis in mice (15')
Brenda Olivier (Amsterdam) Neuronal control of tertiary lymphoid tissue in the inflamed colon (15')
Frieda Koopman (Amsterdam) Stimulation of the vagus nerve as novel anti-inflammatory therapy for rheumatoid arthritis (15')

Session 3: Molecular mechanisms in the development of neuronal circuitry
Chairs: Corette Wierenga & Hilgo Bruining (Utrecht)
Joris de Wit (Leuven, Belgium) Molecular mechanisms of synaptic specificity (30')
Sara Brignani (Utrecht) Pitx3-ITC: a new genetic strategy for dissecting dopaminergic pathway development (15')
Asami Oguro-Ando (Utrecht) CNTN4, a risk gene for autism spectrum disorders, contributes to dendritic morphology of cortical neurons (15')
Cátia Frias (Utrecht) The role of the cell-adhesion molecule Sema4D in bouton dynamics in inhibitory axons (15')
Natalia Goriounova (Amsterdam) Selective suppression of excessive GluN2C expression rescues early epilepsy in tuberous sclerosis (15')

Session 4: Cerebellum; who cares?
Chairs: Freek Hoebeek & Martijn Schonewille (Rotterdam)
Kirsten van Baarsen (Nijmegen) Imaging white matter tracts in the human cerebellum; from validation to clinic (15')
Lieke Kros (Rotterdam) Epileptic absence seizures stopped by closed-loop activation of cerebellar output (15')
Kamran Khodakhah (New York, NY, USA) Cerebellar modulation of basal ganglia plasticity (30')
Dineke Verbeek (Groningen) Elevated Dynorphin A levels and Purkinje cell loss cause cerebellar ataxia in a mouse model of spinocerebellar ataxia type 23 (15')
Zhenyu Gao (Rotterdam) A robust and dynamic feedback loop from the cerebellar nuclei shapes Purkinje cells outputs during eye-blink conditioning (15')

Session 5: Natural Rewards and Addiction
Chair: Heidi Lesscher (Utrecht)
Lique Coolen (Jackson, MS, USA) Sexual behavior in relation to vulnerability to substance abuse (30')
Peter Karel (Nijmegen) Serotonin reuptake inhibition and cocaine sensitivity (15')
Karin Koopman (Amsterdam) Brain serotonin and dopamine transporter binding correlate with visual attention for food in healthy, lean men (15')
Marijke Achterberg (Utrecht) Measuring motivation and performance of social play behavior in rats: role of dopamine and noradrenaline (15')
Heidi Lesscher (Utrecht) Social play deprivation enhances alcohol consumption in rats (15')

Session 6: Genetics of mental disorders: recent findings and novel methods
Chair: Danielle Posthuma (Amsterdam)
Ben Neale (Cambridge, MA, USA) Progress in the genetics of psychiatric illness (30')
Sven Stringer (Amsterdam) GWA survival analysis under a cure model (15')
Christiaan de Leeuw (Nijmegen & Amsterdam) Making sense of gene associations: generalized gene-set analysis for GWAS data (15')
Anke Hammerschlag (Amsterdam) Functional gene-set analysis does not support a role for synaptic function in attention deficit/hyperactivity disorder (ADHD) (15')
Mark Patrick Roeling (Rotterdam) Common genetic variation in microglia is associated with autism spectrum disorders (15')

13:00 Lunch

14:00 Parallel Sessions B
Session 7: Nutrition, stress, and metabolism. A psychoneuroendoimmunological translational perspective
Chairs: Aniko Korosi & Johanna Assies (Amsterdam)
Steven Zeisel (Kannapolis, NC, USA) Choline in early life and brain development (30')
Eva Naninck (Amsterdam) Role of essential micronutrients in the lasting effects of early-life experiences on brain structure and function (15')
Roel Mocking (Amsterdam) Relations between hypothalamic-pituitary-adrenal-axis activity and fatty acid and one-carbon metabolism in depression and post-traumatic stress disorder (15')
Frits Muskiet (Groningen) Brain-selective nutrients critical in contemporary, typical Western, diets (30')

Session 8: Axons, novel insights into plasticity and pathophysiology
Chairs: Casper Hoogenraad (Utrecht) & Maarten Kole (Amsterdam)
Matthew Rasband (Houston, TX, USA) Molecular assembly of electrogenic compartments of axons (30')
Mustafa Hamada (Amsterdam) Grey matter demyelination causes spontaneous network excitability and anomalous ectopic spike generation (15')
Sam van Beuningen (Utrecht) Cytoskeleton organization at the axon initial segment (15')
Somaieh Ahmadian (Leiden) The role of dystrophin in synaptic plasticity of the olfactory circuit (15')
Eljo van Battum (Utrecht) The intracellular redox protein MICAL-1 regulates the development of lamina-specific hippocampal mossy fiber connections (15')

Session 9: Brain connectomics
Chairs: Natalie Cappaert (Amsterdam) & Martijn van den Heuvel (Utrecht)
Kees Stam (Amsterdam) Complex brain networks: the wood and the trees (30')
Rembrandt Bakker (Nijmegen/Jülich/Munich) Do gold standards remain gold standards when compiling a large number of published tract-tracing studies into a connectivity database? (15')
Natalie Cappaert (Amsterdam) Network organization of the (para)hippocampal region in the rat (15')
Marcel de Reus (Utrecht) A central infrastructure for communication and integration in the mammalian brain (15')
Edwin van Dellen (Utrecht) Altered directionality of functional neural interactions in neuropsychiatric disease (15')

Session 10: Depressive disorders: beyond mood. Stress, aggression, cognition and reward
Chairs: Danai Riga & Sabine Spijker (Amsterdam)
Bauke Buwalda (Groningen) Behavioral and neurobiological consequences of adult and adolescent social stress in rats (30')
Ioannis Zalachoras (Leiden) Steroid receptor coactivator-1 isoform switching changes the sensitivity of the central nucleus of the amygdala to glucocorticoids (15')
Leonie Gouweleeuw (Groningen) The role of Neutrophil Gelatinase-Associated Lipocalin in neuroinflammation and depressive symptoms in a rat model of myocardial infarction induced heart failure (15')
Danai Riga (Amsterdam) The deeper the blues, the greater the booze? Depression susceptibility in subsequent vulnerability to alcohol abuse (15')
Jorien Treur (Amsterdam) Spousal concordance and comorbidity for smoking and depressive symptoms (15')

Session 11: Epigenetic mechanisms underlying brain function in health and disease
Chair: Christiaan Vinkers (Utrecht)
Lotte Houtepen (Utrecht) DNA methylation and the endocrine stress response in humans (15')
Bart Rutten (Maastricht) DNMT3a: an epigenetic regulator of cognition? (15')
Marco Boks (Utrecht) Combat trauma exposure and PTSD: a prospective DNA methylation study (15')
Martien Kas (Utrecht) Early environment affects epigenetic programming of neurodevelopmental genes and the susceptibility to adult maladaptive behavior in mice (15')
Jonathan Mill (London, United Kingdom) Epigenetic pathways to neuropsychiatric disease (30')

15:30 Drinks

16:00 Plenary Session
Session 12: Two Top Papers & Thesis Prize

17:30 Drinks

18:00 Plenary Lecture
Session 13: Neurofederation Lecture
Chair: Judith Homberg (Nijmegen)
Bart Ellenbroek (Wellington, New Zealand) Alexander Rudolf Cools – A different individual (60')

19:00 Dinner

20:30 Posters, desserts, and drinks
Session 14: Poster Session 1

22:00 Social (new and improved)

09:00 Parallel Sessions C
Session 15: It’s a lipid’s World. Central control of lipid metabolism
Chairs: Andries Kalsbeek & Hannah Eggink (Amsterdam)
Miguel Lopez (Santiago de Compostela, Spain) Hypothalamic AMPK: a master regulator of energy balance (30')
Serge Luquet (Paris, France) Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding (30')
Hannah Eggink (Amsterdam) Bile acids and the brain (15')
Sander Kooijman (Leiden) Circadian rhythm modulates body fat mass through brown adipose tissue activity (15')

Session 16: Neuron-Glia interactions in the brain
Chairs: Rogier Min & Mark Verheijen (Amsterdam)
Alfonso Araque (Minneapolis, MN, USA) Astrocytes regulate synaptic transmission and plasticity (30')
Rogier Min (Amsterdam) The role of astrocytes in the refinement of the sensory cortex (15')
Anne-Lieke van Deijk (Amsterdam) Astrocyte-lipids in neuron-glia interactions (15')
Mohit Dubey (Amsterdam) Role of astrocytes in Ion water homeostasis in the developing brain (15')
Arne Battefeld (Amsterdam) Neuron oligodendrocyte interactions - more than wrapping axons (15')

Session 17: Targeting synaptic defects in autism spectrum disorders
Chair: Martien Kas (Utrecht)
Peter Scheiffele (Basel, Switzerland) Synaptic pathophysiology in rodent models of autism (30')
Ricarda Braukman (Nijmegen) European researchers unite: functional neuroimaging in infants at-risk for autism (15')
Ahmed Mahfouz (Delft) Co-expression network analysis of the developing human brain transcriptome reveals shared pathways among autism candidate genes (15')
Remco Thedoor Molenhuis (Utrecht) Deletion of Contactin-4 leads to cognitive rigidity in mice (15')
Kim van Elst (Utrecht) The role of dietary polyunsaturated fatty acids in the pathogenesis and treatment of autism spectrum disorders (15')

Session 18: The Ups and Downs of Dopamine - How dopaminergic activity controls behaviour in health and disease
Chairs: Linde Boekhoudt & Geoffrey van der Plasse (Utrecht)
Ana Domingos (Oeiras, Portugal) Lean on circuits or lean for sugar (30')
Roshan Cools (Nijmegen) Contrasting effects of dopamine on human cognition (15')
Malou Dongelmans (Paris, France) Nicotinic control of dopamine activity under uncertainty (15')
Nadia Vendrig (Wageningen) Effects of DREADD-regulated VTA dopamine stimulation: univariate and multivariate analysis of homecage locomotor behaviour (15')
Marianne Klanker (Amsterdam) Rapid changes in phasic dopamine release during spatial reversal learning (15')

Session 19: Specific pathogenic auto-antibodies to neuronal surface proteins in mental illness
Chair: Pilar Martinez-Martinez (Maastricht)
Angela Vincent (Oxford, United Kingdom) Specific pathogenic auto-antibodies to neuronal surface proteins in mental illness (30')
Johann Steiner (Magdeburg, Germany) Are antineuronal antibodies against NMDA receptors potentially relevant in schizophrenia? (30')
Carolin Hoffmann (Maastricht) Analysis of pathogenic autoantibodies against the N-methyl-D-aspartate glutamate receptor in schizophrenia (15')
Lot de Witte (Utrecht) Autoimmunity as a cause of psychosis: Common practice or rare finding? (15')

Session 20: Springer Session

10:30 Coffee/Tea

11:00 Parallel Sessions D
Session 21: Stress, eating and the reward system
Chairs: Merel Rijnsburger & Susanne la Fleur (Amsterdam)
Yvonne Ulrich-Lai (Cincinnati, OH, USA) Stress relief by palatable food reward (30')
Merel Rijnsburger (Amsterdam) Changes in opioid enkephalin and cfos in the nucleus accumbens in rats on a free choice high-fat high-sugar diet (15')
Kit-Yi Yam (Amsterdam) Chronic stress during early life induces persistent alterations in adipose tissue deposition and lipid metabolism (15')
Lu Xu (Nijmegen) Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress (15')
Jennifer ten Kulve (Amsterdam) Endogenous GLP-1 alters activations in central reward and satiety circuits elicited by viewing food pictures in patients with diabetes (15')

Session 22: Synaptic mechanisms in models of Alzheimer's Disease
Chairs: Helmut Kessels & Guus Smit (Amsterdam)
Iryna Benilova (Leuven, Belgium) Role of amyloid-beta alloforms and mutations in pathological oligomerization (30')
David Hondius (Amsterdam) Changes in the human hippocampal proteome during Alzheimer’s disease (15')
Koen Bossers (Amsterdam) Do learning-induced gene expression programs reduce Abeta synaptotoxicity in Alzheimer's disease? (15')
Celine Heldring (Amsterdam) Novel mechanisms of reduced hippocampal plasticity in APPswe/PS1 dE9 mice (15')
Ulrich Eisel (Groningen) Modulation of NMDAR function by TNF in Alzheimer's disease (15')

Session 23: Zebrafish: mice in scales…and beyond
Chairs: Ruud van den Bos & Remy Manuel (Nijmegen)
Robert Gerlai (Mississauga, Ontario, Canada) Social behaviour in zebrafish: an emerging model system with translational power (30')
Ard Peeters (Nijmegen) The use of zebrafish (Danio rerio) larvae in high-throughput drug and genetic screening (15')
Marcel Schaaf (Leiden) Identification of behavioral and genetic determinants of stress axis regulation in zebrafish (15')
Remy Manuel (Nijmegen) Inhibitory avoidance learning in zebrafish (Danio rerio) (15')
Jolle Jolles (Cambridge, United Kingdom) Sociality and the role of personality in sticklebacks: relevant insights from a behavioural ecological perspective (15')

Session 24: Adaptive memories: how representing the past enables future decision-making
Chairs: Lorena Deuker & Branka Milivojevic (Nijmegen)
Dharshan Kumaran (London, United Kingdom) Knowledge from individual experiences: The role of the hippocampus (30')
Branka Milivojevic (Nijmegen) Mapping memory space - flexible integration and segregation of events within memory networks (15')
Renée Visser (Amsterdam) Markers for memory: assessing neural pattern similarity in the study of associative fear (15')
Ineke van der Ham (Utrecht) Order memory in navigation: based on space or time? (15')
Peter Smulders (Nijmegen) Hippocampal predictions and decision making (15')

Session 25: Patient-derived induced pluripotent stem cells for in vitro and in vivo modeling of neurological diseases
Chair: Vivi Heine (Amsterdam)
Frank Edenhofer (Wurzburg, Germany) Novel routes of neural reprogramming: direct conversion of somatic cells into neural stem cells (30')
Stephanie Dooves (Amsterdam) Transplantation of glial progenitor cells in a mouse model of Vanishing White Matter disease (15')
Arun Thiruvalluvan (Groningen) Development of an iPS cells-based model of ataxin-3 aggregation (15')
Koen van Zomeren (Groningen) Oligomeric α-synuclein toxicity in human dopaminergic neurons (15')
Anna Bennis (Amsterdam) Toward stem cell based therapy for diseases which affect the retinal pigment epithelium (15')

Session 26: Neuroscience for society: the neuro-education case
Chair: Harold Bekkering (Nijmegen)
Roi Cohen Kadosh (Oxford, United Kingdom) Harnessing plasticity in the atypical developing brain (30')
Esther Keulers (Maastricht) Maturation of task-induced brain activation and functional connectivity in adolescence (15')
Kim Veroude (Amsterdam) The neural basis of cognitive control in medical students (15')
Lea Hald (Nijmegen) Optimizing word learning via sensorimotor information (15')
Kiki Zanolie (Leiden) Social cognition in adolescence (15')

12:30 Posters & Lunch
Session 27: Poster Session 2

14:00 Parallel Sessions E
Session 28: The rebirth of the bed nucleus of the stria terminalis; integration of stress and mood
Chair: Tamas Kozicz (Nijmegen)
Thomas Kash (Chapel Hill, NC, USA) Neurophysiological alterations in the bed nucleus of the stria terminalis underlying dysregulated emotional behavior (45')
Marloes Henckens (Rehovot, Israel) The posterior bed nucleus of stria terminalis is crucial for adequate stress recovery; an optogenetics approach (15')
Floris Klumpers (Nijmegen) Dissociable roles of the human BNST and amygdala in imminent threat responses versus threat anticipation (15')
Rick van der Doelen (Nijmegen) Early life stress, serotonin transporter gene variation and the bed nucleus of the stria terminalis (15')

Session 29: Cell-to-cell transfer mechanisms in neurodegenerative disease
Chair: Wiep Scheper (Amsterdam)
Chiara Zurzolo (Paris, France) Role of Tunneling Nanotubes (TNTs) in intercellular spreading of prions and other protein assemblies involved in neurodegenerative diseases (30')
Michiel Pegtel (Amsterdam) Exosomes as mediators of intracellular communication in the CNS (15')
Sue Godsave (Amsterdam) Prion replication, spreading and pathology in vivo – a cryo-immunogold EM assessment of prion-infected mouse hippocampus (15')
Wiep Scheper (Amsterdam) Cell-to-cell transfer mechanisms in Alzheimer's disease (15')
Marcel Verbeek ( Nijmegen) Does cell-to-cell transfer of pathogenic proteins correlate with CSF biomarkers in neurodegenerative disorders? (15')

Session 30: New approaches to study neuronal ensembles encoding learned behavior
Chairs: Michel van den Oever (Amsterdam) & Steven Kushner (Rotterdam)
Bruce Hope (Baltimore, Maryland, USA) Neuronal ensembles in addiction (30')
Steven Kushner (Rotterdam) Characterizing fear memory engrams in the hippocampus (30')
Michel van den Oever (Amsterdam) Optogenetic and pharmacogenetic dissection of a cocaine memory-trace (15')
Geoffrey van der Plasse (Utrecht) Midbrain dopaminergic involvement in food seeking behavior (15')

Session 31: What’s eating you? Cognitive and affective influences on food-related brain activation and eating behaviour
Chairs: Aimee Capello (Maastricht) & Paul Smeets (Utrecht)
Todd Hare (Zurich, Switzerland) The effects of acute stress on behavioral and neural measures of dietary self-control (30')
Aimee Capello (Maastricht) Effects of repeated tryptophan administration on stress-induced cortisol and appetite: influence of genetic 5-HT vulnerability and trait stress-sensitivity (15')
Nynke van der Laan (Utrecht) Temptation strength and self-regulatory success modulate activation in inhibitory brain regions during food choice in weight-concerned women (15')
Joost Wegman (Nijmegen) Neural top-down influences of food labeling on implicit food wanting (15')
Karolien van den Akker (Maastricht) Partial reinforcement of food cues, impulsivity, and the extinction and reacquisition of appetitive responses. Possible implications for (un)successful dieting (15')

Session 32: On the versatility of the endocannabinoid system; from psychoactive drug to therapeutic applications
Chairs: Eef Theunissen (Maastricht) & Matthijs Bossong (London)
Maria Grazia Cascio (Aberdeen, United Kingdom) The endocannabinoid system: an overview (30')
Andras Bilkei-Gorzo (Bonn, Germany) Cannabinoid system activity protects against brain ageing (15')
Joost Wiskerke (Princeton, NJ, USA) Conditioned heroin seeking in rats is associated with enhanced extracellular levels of the endocannabinoid 2-AG in the medial prefrontal cortex (15')
Chris Schubart (Blaricum) Cannabis beyond good and evil. How genetic and epidemiological factors shape the relationship between cannabis and psychosis (15')
Matthijs Bossong (London, United Kingdom) Cannabidiol as a treatment in the early phase of psychosis (15')

15:30 Drinks

16:00 Young Talent Prize and Plenary Lecture
Session 33: Netherlands Brain Foundation Lecture
Chair: Sabine Spijker (Amsterdam)
Patrick Sullivan (Chapel Hill, NC, USA) The genomics of Schizophrenia: new knowledge & new challenges (60')

17:30 Closure ENP 2014

If your abstract is selected for a poster presentation, when preparing your poster please remember that the area available to you is 90 x 110 cm (width x height).

"Portrait" is fine      "Landscape" not...

Please ensure that the corresponding number is clearly indicated on the poster itself (check the poster lists). Your poster should be readable from a 2-meter distance; as a rough guideline, use a font size of 72 pts for your title, and a minimum of 28 pts for your text.

Posters must be mounted on the day of the presentation between 08:00 and the start of the first session of the day (9:50 on Thursday, and 09:00 on Friday). Posters should only be removed at the end of the day.